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MBMR Biolabs portfolio offers some of the most cutting-edge products in bio-orthogonal chemistry.

The inverse-electron demand Diels Alder cycloaddition (tetrazine cycloaddition) between trans-cyclooctenes and tetrazines is biocompatible and exceptionally fast. A variety of applications has been developed that utilize tetrazine cycloaddition to image and retrieve nucleic acids, proteins, glycans, lipids, and other metabolites in vitro, in cells as well as in whole organisms. By tagging these biomolecules, researchers can monitor their dynamics in living systems and discover specific substrates of cellular pathways. Additionally, tetrazine conjugation has allowed development of novel diagnostic tools, including radiochemical labeling of macromolecules for pretargeted SPECT/CT imaging of tumors in live mice.

We aim to provide comprehensive solutions that will enable researchers of diverse scientific disciplines to utilize tetrazine bioconjugation in their work. We thank you for your interest in our company and invite you to collaborate with us.

Technology

Bioorthogonal reactions for coupling functional chemical entities in vitro and in vivo are of great interest in life sciences and medicine.  MBMR Biolabs focuses on the the development of new applications for the inverse-electron-demand Diels-Alder cycloadditon (also called tetrazine cycloaddition) – a copper-free  click chemistry reaction, developed in the laboratory of Professor Joseph M. Fox at University of Delaware.

The inverse-electron-demand Diels-Alder cycloaddition between trans-cyclooctenes and tetrazines is biocompatible and exceptionally fast.  The rate for Diels-Alder cycloaddition, reported to be as high as 2000 M-1 s-1, is on par with the rate for canonical copper-catalyzed azide-alkyne conjugation.  However, Diels Alder reaction does not exhibit the accompanying cell toxicity that prevents usage of those reagents in vivo or inside living cells in a variety of applications.

Due to their small size and advantageous photophysical properties relative to fluorescent proteins, chemical fluorophores have the potential to be very useful for live cell imaging. Here we are presenting a variety of reagents that have been described in literature as building blocks for site-specific protein labeling, specific intracellular protein labeling, lipid labeling, as well as tumor imaging in live animals.  We are currently working on the development of more kits to be used both with in vitro and in vivo applications.

Board of Directors

Joseph M. Fox, PhD

Dr. Fox is a professor at University of Delaware and also an inventor of the inverse electron demand Diels-Alder reaction.  His lab centers on the development of new types of chemical reactions, the application of these new reactions to the synthesis of natural occurring and designed molecules with biological function, and the use of design concepts in organic synthesis for applications in materials science.  Dr. Fox graduated in Chemistry, earning his A.B. from Princeton University, and his PhD from Columbia University.  He then went on to complete his postdoctoral training at the Massachusetts Institute of Technology before starting his own lab at the University of Delaware in 2001.  He is an author of more than 116 articles and his work was cited in more than 2422 scientific publications.

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Contact

Corporate Headquarters:

760 Parkside Avenue Room 205

New York, NY 11226

email:  info@mbmrbiolabs.com

phone: 1 866 248 5556