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Strained trans-cyclooctene 4-nitrophenyl carbonate

Compound Information:

  • MBMR0007
  • C17H19NO
  • 317.3
  • White powder
  • -20o C

References

Taylor, MT, Blackman ML, Dmitrenko, O, Fox, JM: Design and synthesis of highly reactive dienophiles for the tetrazine-trans-cyclooctene ligationJ Am Chem Soc 2011 133:9646-9649.

Selvaraj, R., Fox, JM.  trans-Cyclooctene – a stable, voracious dienophile for bioorthogonal labeling.    Curr. Opin. Chem. Biology, 2013, S1367-5931 (13) [Epub ahead of print].

Šečkutė J., Devaraj, N Expanding room for tetrazine ligations in the in vivo chemistry toolbox.   Curr. Opin. Chem. Biol., 2013, 1367-5931 (13) [Epub ahead of print].

Blackman, M, Royzen, M., Fox, JM.  Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivityJ. Am. Chem. Soc., 2008, 130, 13518–13519